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DMT, or N,N-Dimethyltryptamine, is a naturally occurring chemical found in both plants and animals. It is the active hallucinogenic compound in ayahuasca, the Quechua name for a tea brewed from the shrub Psychotria viridis, which is used for ritual purposes by the indigenous people in the Amazon. See our ayahuasca guide for more on this psychedelic brew.DMT can also be ingested in crystal form, where it is often smoked in a pipe or bong. Taken in this manner, it produces a powerful but short-lasting hallucinogenic state that is considered one of the most intense psychedelic experiences in existence.It can also retain its psychoactive properties in other forms, including psilocybin (4-PO-DMT, found in psilocybin mushrooms).
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PHARMACOLOGY DMT is primarily a serotonin (5-HT) receptor agonist and, like many other hallucinogens, its psychedelic actions can mostly be attributed to its effects on the 5-HT2A receptor subtype. It does affect many other receptor types (for example, dopamine and sigma receptors), but the consequences of these interactions are not well understood.
Ayahuascasaftey.org lists many substances you should avoid or use caution with if you’re planning an ayahuasca/DMT trip.DMT significantly affects the serotonin system and should not be taken simultaneously with any of the following substances - SSRI’s (any selective serotonin reuptake inhibitor, like Prozac) - antihypertensives (high blood pressure medicine) - appetite suppressants (diet pills) - medicine for asthma, bronchitis, or other breathing problems; antihistamines, medicines for colds, sinus problems, hay fever, or allergies (any drug containing dextromethorphan/ DXM or with DM, DX or Tuss in its name) - CNS (central nervous system) depressants (xanax, ativan, etc) - Vasodilators - Antipsychotics - Barbiturates - Alcohol
Recreational drugs that are VERY dangerous to combine with MAOIs: --Cocaine --amphetamines (meth-, dex-, amphetamine), ephedrine, MDMA (Ecstasy), MDA, MDEA, PMA --opiates (heroin, morphine, codeine, and especially opium) --dextromethorphan (DXM) --Nutmeg --mescaline (any phenethylamine) --barbiturates --alcohol --kratom --kava --5-MEO-DMT The psychedelic threshold for DMT is about 0.2 mg/kg. When smoked, it’s a very fast-acting substance with peak subjective experience occurring around 2 minutes after ingestion, and completely resolving within 15 to 20 minutes.When taken as an ayahuasca brew, the effects can take up to an hour to appear, and may last for several hours. A study in the 1990s examined the dose effects of intravenous DMT at 0.05, 0.1, 0.2 and 0.4 mg/kg in a double-blind, randomized design, using 12 volunteers. The Hallucinogen Rating Scale (HRS), that was developed and used for this study, grouped responses into six clinical categories: Affect, Volition, Somatic Effects (‘Somaesthesia’),Perception, Cognition, and Intensity.The ‘psychedelic’ threshold for DMT was at 0.2 mg/kg, at which most biological effects were also detectably altered. Adrenocorticotropin hormone, beta-endorphin, prolactin, growth hormone (GH) and cortisol were all elevated following DMT administration. Pupil diameter, heart rate, blood pressure and all peaked within 2 min as did subjective experiences.No evidence of tolerance (needing to take more for the same effect) for DMT was found in a later trial.
Low doses (0.05 to 0.1 mg/kg) of DMT primarily affect physical and emotional states with few to no perceptual hallucinations. Higher doses typically produce a rapidly moving kaleidoscopic displays of intensely “techno-colored” abstract and representational images. Auditory hallucinations are less common and usually aren’t a very prominent feature of the experience. Alternating sensations of heat and cold are sometimes reported.Transient states of anxiety are quite common, though so are euphoric states and, somewhat paradoxically, they can be experienced simultaneously. Out-of-body experiences, or a dissociation of awareness from the physical body, is very common with DMT (at higher doses) to the point that many consider it a hallmark of the experience. In his book, The Spirit Molecule (2000), Rick Strassman describes studies in which about half of the volunteers during a DMT trip entered “freestanding, independent levels of existence” - psychological planes of existence that were often inhabited by “intelligent beings”, “entities”, “aliens”, “guides” and “helpers”. Terrence McKenna called these “machine elves”. According to Strassman’s work, they take the form of “clowns, reptiles, mantises, bees, spiders, cacti and stick figures.” Reports of these kinds of beings seem to be unique to DMT trips. While the therapeutic value of DMT alone has not been explored to the extent that other psychedelic drugs have, the DMT-containing brew ayahuasca has long been used traditionally to treat various psychological maladies, including mood disorders and addiction. Ayahuasca has seen an increase in use in the modern world as a potential treatment of depression and addiction. A review of six studies between 1990 and 2015 found that ayahuasca (along with LSD and psilocybin) holds promising potential for treating depression, anxiety, and tobacco addiction, and alcoholism. Researchers have proposed that ayahuasca’s therapeutic effects come from its ability to induce greater mindfulness in users.Following an ayahuasca experience, decreases in self-judgment and emotional reactivity to inner experiences help foster a sense of self-acceptance, widely agreed to be a critical step in healing mood and addictive disorders